Might be a reference to an urban legend from the 1950s, about a young woman dying as a result of a nest of poisonous spiders lodging without her knowing in her voluminous bouffant hairdo.
Possible reference to The Longest Yard (1974). Bert Reynolds asks Bernadette Peters if she ever finds spiders in her hair. Peters has a beehive hairdo much like that worn by the character in this film (whom she also resembles).